Breathing in dust or other particles present in the air such as coal dust, farm dust, asbestos fibers, iron from mines, welding fumes, or silica dust cause some types of interstitial lung diseases, while others have no identified cause. Interstitial lung disease has been reported 97 times by Crestor patients. Muscle ache is common. Is there a risk of rhabdomyolysis from statins? Learn how and why people stop taking statins here. This is still being studied. Cholesterol medications: Consider the options. Cholesterol test kits: Are they accurate? Rarely, statins can cause more serious problems. The pain can be a mild discomfort, or it can be severe enough to make your daily activities difficult. While you won't need to eliminate grapefruit entirely from your diet, ask your doctor about how much grapefruit you can have. Drug-induced diabetes mellitus: Evidence for statins and other drugs affecting glucose metabolism. Mayo Clinic does not endorse companies or products. Some patients decide to stop taking statins, a cholesterol-lowering drug, if they experience side effects. (2017, July 5). Some drugs that may interact with statins and increase your risk of side effects include: There are many drugs that may interact with statins, so be sure your doctor is aware of all the medicines you take when being prescribed with statins. There are some reports on changes in mood on statins. Six of these cases resulted in death, 65 in hospitalization, eight in disability, and eight were life-threatening. In addition to interstitial lung disease, post-marketing reports link Crestor and Lescol to the following serious medical events, including: TruLaw continues to monitor cholesterol-lowering statin drugs for some serious adverse events that have been reported to the FDA but are not currently listed in the drug’s current prescribing information, including headaches, myalgia, abdominal pain, asthenia, and nausea. Past success in litigation does not guarantee success in any new or future lawsuits. It is important to be aware that normal levels of "CK" do not exclude a relation to statins. To relieve side effects believed to be caused by statins, your doctor may recommend several options. Note: This document contains side effect information about rosuvastatin. Since statins can cause muscle damage, they could theoretically also harm the heart--which is, essentially, a big muscle--although there is no evidence that this is the case. However, statin drugs reduce the production of cholesterol and slow the formation of new plaques, sometimes reduce the size of already existing plaques, and stabilize plaques and make them less prone to rupturing. Remember that statin medications can reduce your risk of a heart attack or stroke, and the risk of life-threatening side effects from statins is very low. Although cholesterol is essential to the normal function of every cell in the body, it also contributes to the development of atherosclerosis, a condition in which cholesterol-containing plaques begin to form within the arteries, reducing the flow of blood to the tissues that the arteries supply. See below for a comprehensive list of adverse effects. Rhabdomyolysis can occur when you take statins in combination with certain drugs or if you take a high dose of statins. 2018;12:757. Mayo Clinic does not endorse any of the third party products and services advertised. There has also been evidence that statins may help with brain function — in people with dementia, for example. The U.S. Food and Drug Administration requires that warning labels state that statins can cause memory loss as well as mental confusion, liver problems, and type 2 diabetes. Muscle damage can occur and in rare cases it may become serious.There appears to be increased risk of diabetes on statin therapy. Rhabdomyolysis can occur when you take statins in combination with certain drugs or if you take a high dose of statins. In: Ferri's Clinical Advisor 2019. Beta (β) blockers stop the action of epinephrine (adrenaline) and norepinephrine (noradrenaline) on your lungs. Jessica can be reached at 888-878-5295 or via email at Jess@TruLaw.com. The problem can be easily detected by observing the color of the urine, which will be dark brown. Safety and efficacy of statin therapy. Arcus senilis: A sign of high cholesterol? https://www.uptodate.com/contents/search. Talk to your doctor to see if a change of dosage or even a different type of medication might be helpful. TruLaw works with experienced lawyers who are prepared to fight on behalf of individuals harmed by these same drugs, devices, chemicals and other products. Jessica Paluch Hoerman is licensed to practice in Illinois. The actual risk of developing muscle pain as a result of taking statins is about 5 percent or less compared with taking a pill that doesn't contain medication (placebo). Asthma and COPD are among the most prevalent … Rarely, statins may cause liver damage or liver failure, both of which could trigger abdominal pain. Accessed Jan. 29, 2019. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Statin drugs lower the level of cholesterol in the blood by decreasing the production of cholesterol by the liver. Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Statin side effects: Weigh the benefits and risks, Newsletter: Mayo Clinic Health Letter — Digital Edition, Book: Mayo Clinic Family Health Book, 5th Edition. If any of the reactions below happens to you, stop taking the statin and contact your doctor immediately. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Statin muscle-related adverse events. Some studies suggest such problems may be much more common than is recognised. ... read about why statins cause muscle pain. (2017, August 4). It's possible your blood sugar (blood glucose) level may increase when you take a statin, which may lead to developing type 2 diabetes. If you think you're experiencing side effects from statins, don't just stop taking the pills. TruLaw does not offer any guarantee of case results. The benefit of taking statins likely outweighs the small risk to have the blood sugar level go up. Dr Sarah Jarvis says: Unfortunately, all drugs can cause side effects for some people, and statins are no exception. While the benefits of statin therapy in COPD can be rationally explained by the known pharmacological effects of statins on the lungs, [5,13,14] and … Adverse effects of statin therapy: Perception vs. the evidence — focus on glucose homeostasis, cognitive, renal and hepatic function, haemorrhagic stroke and cataract. An attorney/client relationship with TruLaw, LLC is established only by an express and written agreement by TruLaw, LLC to represent you. Although may be caused by variety of factors, these factors are usually rooted in lung-related and heart-related conditions. © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). Although liver problems are rare, your doctor may order a liver enzyme test before or shortly after you begin to take a statin. Rhabdomyolysis can cause severe muscle pain, liver damage, kidney failure and death. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Statins: Actions, side effects and administration. Nsouli says he became interested in the question after he noticed that many of his asthma patients who started statin therapy saw their breathing problems escalate. Statin-induced muscle syndromes. The increase generally occurs when blood sugar levels are already higher than normal and fall in the prediabetes or diabetes range when you begin taking a statin. Anyanwagu U, et al. European Heart Journal. (2017, February 2). A Dutch survey of 4,738 statin users asked about side effects. The hypothesis is that the statins cause blood flow to the brain to reduce in favor of flow to the heart, although there is no firm evidence that this is happening. Other side effects can be very severe, such as … These are not all the side effects of atorvastatin. Statins can lead to diabetes at an alarming rate. Just over a … Rosenson RS, et al. An attorney/client relationship with TruLaw, LLC is established only by an express and written agreement by TruLaw, LLC to represent you. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Rare side effects of all statins. Statins work by blocking hydroxy-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), the enzyme in the liver that is responsible for producing cholesterol. Statins are a type of drug that help to reduce cholesterol levels in patients. Retrieved October 16, 2017, from, Ogbru, O., & Marks, J. W. (2016, May 19). AskMayoExpert. When plaques rupture, a blood clot forms on the plaque, further blocking the artery and hampering blood flow. Numerous side effects are associated with statins and these side effects can often deter patients from using the drug. The study wasn't able to prove that statins caused the increase in breathing problems. Memory problems or loss. When blood flow is reduced in the arteries that supply the heart, chest pain or a heart attack will result; if blood flow to the brain is reduced, a stroke will result; and if plaques in the arteries of the leg reduce blood flow there, intermittent claudication (pain in the legs while walking) will occur. Statins are a type of medication that doctors prescribe to lower levels of 'bad' cholesterol and reduce the risks of heart attack and stroke. They were confused and wondered what was causing her worsening breathing problems/shortness of breath and chronic coughing. If you or a loved one were injured by a drug or medical device, you may be entitled to compensation. This may happen to one person in a 1,000 who takes statins. Advertising revenue supports our not-for-profit mission. Statins, previously tested in patients with chronic obstructive pulmonary disease (COPD) and asthma, may get a second wind. This causes your liver to remove cholesterol from your blood. Statins are effective at lowering cholesterol and protecting against a heart attack and stroke, although they may lead to side effects for some people. Rhabdomyolysis can cause severe muscle pain, liver damage, kidney failure and death. Nature Reviews Cardiology. Wilson's syndrome: An accepted medical diagnosis? Cholesterol ratio or non-HDL cholesterol: Which is most important? Fasting diet: Can it improve my heart health? A new study tracked how they did. The risk of very serious side effects is extremely low, and calculated in a few cases per million people taking statins. All rights reserved. Retrieved from, Drug safety labeling changes (SLC). Side effects of statins. In Summary. The risk of very serious side effects is extremely low, and calculated in a few cases per million people taking statins. One of the most common complaints of people taking statins is muscle pain. After a flood, are food and medicines safe to use? However, researchers have found a "nocebo" effect when it comes to perceived muscle pain and statins. Brand name examples include Altoprev, Crestor, Lescol, Lipitor, Livalo, Mevacor, Pravachol, and Zocor. Adrenaline helps to relax the small airways of your lungs and make breathing easier. 2018;39:2526. The researchers admitted that more work is needed to answer questions regarding surgery and statins, and they did not recommend stopping statins before surgery until more is known. Hypothyroidism: Can calcium supplements interfere with treatment? There is limited evidence to prove a cause-effect relationship, but talk to your doctor if you experience memory loss or confusion while taking statins. The Instant Case Evaluator ℠ provides consumers with an instant legal analysis free of charge. Adhyaru BB, et al. 1 Because statins have anti-inflammatory and anti-oxidative effects, researchers are examining how the drugs can reduce exacerbations leading to emergency treatment and hospitalization in both conditions. Journal of Atherosclerosis and Thrombosis. Food and Drug Administration. FREE book offer – Mayo Clinic Health Letter, Statin side effects Weigh the benefits and risks, Advertising and sponsorship opportunities, Taking multiple medications to lower your cholesterol, Having certain conditions such as hypothyroidism or neuromuscular disorders including amyotrophic lateral sclerosis (ALS), Amiodarone (Cordarone, Pacerone), a medication for irregular heart rhythms, Gemfibrozil (Lopid), another variety of cholesterol drug, HIV treatments called protease inhibitors such as saquinavir (Invirase) and ritonavir (Norvir), Some antibiotic and antifungal medications, such as clarithromycin and itraconazole (Onmel, Sporanox), Some immunosuppressant medications, such as cyclosporine (Gengraf, Neoral, Sandimmune). The FDA warns on statin labels that some people have developed memory loss or confusion while taking statins. Ferri FF. Lopez-Jimenez F (expert opinion). Accessed Jan. 24, 2019. Allergic reaction that causes your face, tongue and throat to swell and makes it … Don't stop taking your statin medication before talking to your doctor. Jessica can be reached at. Sending or receiving information through this site, posting to our blogs/news site does not establish an attorney/client relationship. Even if your side effects are frustrating, don't stop taking your statin medication for any period of time without talking to your doctor first. If you have read about the potential side effects of statins, you may be more likely to blame your symptoms on the medication, whether or not they're truly caused by the drug. TruLaw does not offer any guarantee of case results. Occasionally, statin use could cause an increase in the level of enzymes that signal liver inflammation. Mach F, et al. Jessica Paluch Hoerman is the attorney responsible for its content. 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What was causing her worsening breathing problems/shortness of breath and chronic coughing who takes statins in disability, and....: can it improve my heart health new or future lawsuits, do n't just stop taking the pills statins! Or even a different type of medication might be helpful the risk diabetes. 4,738 statin users asked about side effects believed to be caused by statins, a blood clot forms the. Labels that some people have developed memory loss or confusion while taking statins Ogbru, O., Marks! See if a change of dosage or even a different type of medication might be helpful effects extremely!